Abstract
Traskman-Bendz, Lil, Marie Asberg, Peter Nordstrom and Michael Stanley: Biochemical Aspects of Suicidal Behavior. Prog. Neuropsychopharmacol. & Biol. Psychiat. 1989, 13 (Suppl): S35–S44 1. 1. In completed suicides, studies of brain regions and CSF indicate a dysfunction of the serotonergic system. 2. 2. In suicidal patients, regardless of diagnoses, analyses of monoamine metabolites in lumbar CSF reveal decreased concentrations of the serotonin metabolite 5-HIAA. 3. 3. In depressed suicidal patients,both low CSF 5-HIAA and low concentrations of the dopamine metabolite HVA are associated with suicidality.In addition, pathological dexamethasonetests may indicate an increased suicide-risk in these patients. 4. 4. In depressed patients, there is evidence that the association between CSF 5-HIAA and corticosteroids is in contrast to findings in depressed suicidal patients.
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