Abstract

Following their synthesis in and export from the nucleus, quite a few mRNA molecules get sorted to specific cellular locations. These events are linked to particular biological activities in which localized protein expression or asymmetrical RNA inheritance after cell division has regulatory relevance. The most prominent examples for regulatory phenomena which are based upon RNA localization are illustrated in Fig. 1. Here, rather than providing a detailed reflection of such biological implications, we will focus on the RNA biochemistry and molecular mechanisms that allow for subcellular RNA localization.

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