Biochemical and Toxicological Activity of Guiera senegalensis Leaves Extract

Abstract

Guiera senegalensis (“Senegal guiera” in English; “Sabara” in Hausa) (Combretaceae) is traditionally used for various purposes in Africa and other parts of the world with little or no scientific basis. It is thus the aim of this research to evaluate its biochemical and toxicity effects for its medicinal properties, safety, efficacy of treatment, and the optimum dose. The study qualitatively screened for phytochemicals, acute toxicity (LD50) and sub-chronic toxicity indices in the ethylacetate extract of the plant. The result of phytochemical screening revealed G. senegalensis ethylacetate leaf extract to contain some important phytochemical compounds that may attribute to the biochemical properties possessed by the plant. The result of acute toxicity study showed that the plant is practically non-toxic (oral LD50>5000mg/kg) when used for a short period of time and some signs of toxicity on heart in sub-chronic study (on long term of use). Also, the Haematological results indicated that the plant may have some effects on the immune system, might have caused an increase in RBC and haemoglobin production, and may also enhance O2 – transport capacity of the blood. Guiera senegalensis should therefore be used with care when used for a long period of time.