Biochemical and tensometric analysis of C(60) fullerenes protective effect on the development of skeletal muscle fatigue

D M Nozdrenko,Taras Shevchenko National University Of Kyiv, Ukraine ,Taras Shevchenko National University Of Kyiv, Ukraine; , ,Lesya Ukrainka Volyn National University, Lutsk, Ukraine ,O M Abramchuk,Yu I Prylutskyy,I V Pampuha,O O Gonchar,K I Bogutska

doi:10.15407/ubj93.04.093

Abstract

Biochemical and tensometric analysis of C(60) fullerenes protective effect on the development of skeletal muscle fatigue

Highlights

Skeletal muscles are able to perform physical work only for a certain period of time, the duration of which is inversely proportional to the amount of load, after which there is a gradual decrease in the maximum level of strength that can be generated and maintained by skeletal muscle
One of the important unresolved issues is still the physiological difference between the formation of rapid muscle fatigue and its slow onset. This is primarily due to the adaptive correction of muscle fatigue processes, which do not take into account the fast and slow ways of its development
The development of muscle fatigue disrupts the activity of antioxidant enzymes, induces the oxidation of glutathione, which belongs to the non-enzymatic part of the antioxidant system of protection of the cell from free radicals, which leads to a general decrease in its concentration [11]

Summary

Introduction

Skeletal muscles are able to perform physical work only for a certain period of time, the duration of which is inversely proportional to the amount of load, after which there is a gradual decrease in the maximum level of strength that can be generated and maintained by skeletal muscle. This phenomenon is called muscle fatigue [1, 2]. The first is accumulation of metabolic products (lactic acid, free radicals, etc.) during muscle contraction Some of these products, as well as potassium ions, diffuse from the fibers to the outside and inhibit the ability of the stimulated membrane of myocytes to generate action potentials. The development of muscle fatigue disrupts the activity of antioxidant enzymes, induces the oxidation of glutathione, which belongs to the non-enzymatic part of the antioxidant system of protection of the cell from free radicals, which leads to a general decrease in its concentration [11]

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Conclusion