Biochemical and Structural Characterization of the Tautomycetin Thioesterase: Analysis of a Stereoselective Polyketide Hydrolase

Abstract

Tautomycetin (TMC) is a polyketide metabolite produced by Streptomyces sp. CK4412 and Streptomyces griseochromogenes.[1] This intriguing molecule was previously shown to possess activated T-cell specific immunosuppressive activity with a novel mode of pharmacological action, both in vivo and in vitro.[2] More recent studies have also revealed promising anticancer activity in a variety of models.[3–5]