Biochemical and molecular perspectives on polyphenol rich food, probiotic food, and their combination

Farid E Ahmed,Mostafa Gouda,Laila Hussein,Nancy C Ahmed,Paul W Vos,Mohamed Mahmoud

doi:10.15761/ifnm.1000229

Abstract

Biochemical and molecular perspectives on polyphenol rich food, probiotic food, and their combination

Highlights

Disease modulation by nutrientsThe WHO in 2011 predicted that by 2030, cardiovascular diseases will remain the leading causes of death, affecting approximately 23.6 million people worldwide [1]
Probiotic bacteria contribute to lowering plasma hyper cholestrolemia due to the proposed mechanism mediated by the probiotic bile salt hydrolase (BSH) activity
Suitability of stool as a medium for developing a sensitive molecular biomarker screen Stool represents a challenging environment, as it contains many substances that may not be consistently removed in PCR, in addition to the presence of certain inhibitors, which all need to be removed for a successful PCR reaction

Summary

Introduction

Disease modulation by nutrientsThe WHO in 2011 predicted that by 2030, cardiovascular diseases will remain the leading causes of death, affecting approximately 23.6 million people worldwide [1]. Hypercholesterolemia represents the first stage of atherosclerosis, a risk factor for Chronic Heart Disease (CHD) [2]. Research suggests that about one-third of all cancer deaths are attributable to poor nutrition, physical inactivity, and overweight or obesity; and these risk factors may account for up to 80% of large bowel, breast, and prostate cancers. Probiotic bacteria contribute to lowering plasma hyper cholestrolemia due to the proposed mechanism mediated by the probiotic bile salt hydrolase (BSH) activity. This probiotic enzyme hydrolyses conjugates glycodeoxycholic acid and taurodeoxycholic acid to hydrolysis products, which inhibit the absorption of cholesterol and suppress the reabsorption of bile acid [7]

Methods

Results

Conclusion