Biochemical and histopathological changes caused by Atorvastatin in Gentamicin treated rats.

Abstract

Introduction: Gentamicin is a member of antibiotic group (aminoglycosides), it's very effective in the management of many gram negative bacterial infections but its nephrotoxic effect is considered the major limiting factor. The protective role of Atorvastatin against this adverse effect in male rats was investigated in this study. Materials and methods: thirty adult Wistar male rats were included in the study, they were divided into 3 groups randomly with ten rats in each one, rats in group (1) were given normal standard diet and considered as control. Rats in group (2) were given gentamicin in a dose of 100 mg per kg per day, intraperitoneally for four weeks, while rats in group (3) were given gentamicin in a dose of 100 mg per kg per day, intraperitoneally together with atorvastatin 10 mg per kg per day orally for four weeks. Results: treatment with Gentamicin elevated the level of serum urea, cystatin C, creatinine, total oxidant status and tissue malondialdehyde (MDA) significantly while decreased total antioxidant status significantly. Treatment with Atorvastatin decreased the level of serum urea, creatinine, total oxidant status and tissue MDA significantly while increased total antioxidant status significantly. Renal damage in gentamicin treated rats was determined markedly with histopathological studies in the glomeruli and renal tubules. Conclusion: coadministration of statins with gentamicincan can reduce the nephrotoxicity induced by gentamicin treatment.