Abstract
We determined the primary structures of murine senile amyloid protein (ASSAM) which was isolated from the livers of accelerated senescence prone mice (SAM-P) and apo SASSAM, wnich has a common antigenicity with ASSAM in the serum, derived from slc:ICR mice. ASSAM consists of a single polypeptide chain of 78 amino acid residues, of which the amino-terminus is blocked with pyrrolidone carboxylic acid and the amino acid sequence of ASSAM differs from those of the known amyloid proteins. Apo SASSAM is the murine apolipoprotein (apo) A-II because high homology is present between the primary structures of apo SASSAM and human apo A-II. Sequence comparison between ASSAM and apo SASSAM revealed that ASSAM is an apo A-II variant with one amino acid substitution of glutamine for proline at position 5.
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