Abstract
Rats were given thallium acetate (5 mg of thallium/kg) ip daily for 7 days. The corpus striatum was removed, and several enzymes and protein estimations were made. Succinic dehydrogenase, monoamine oxidase, acid phosphatase, guanine deaminase and protease (cathepsin) activities in the corpus striatum were depleted by thallium, whereas adenosine triphosphatase and adenine deaminase activity were unaffected. Protein content of the corpus straitum was significantly increased, which could be due to a depletion of cathepsin and acid phosphatase; sulfhydryl-dependent enzymes were particularly depleted. Single neuron activity of the caudate nucleus, recorded after iv injection of thallium acetate (10 mg/kg body weigh), showed an increased firing rate of the caudate neurons, which could possibly be due to an imbalance of neurotransmitters.
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