Abstract
BackgroundAsthmatic bronchitis is a chronic allergic airway disease diagnosed after development of chronic obstructive pulmonary disease symptoms. This study was designed to reveal relation of the different electrophoretic patterns to impairment of the lung functions in patients with asthmatic bronchitis.Materials and methodsPatients were categorized into patients at mild stage (n = 10) and those at severe stage (n = 12) in comparison to healthy group (n = 21). The major blood components, arterial blood gases and electrolytes were immediately assayed in addition to assessment of liver enzymes and kidney functions. The pulmonary indices including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), ratio of FEV1 to FVC and maximal expiratory pressure (MEP) were assayed. Furthermore, protein, lipid and calcium moieties of native protein patterns in addition to isoenzemes were electrophoretically detected.ResultsIt was found that liver and kidney functions were significantly (P < 0.05) elevated in asthmatic bronchitis patients. Ca2+ is the only electrolyte that decreased significantly (P < 0.05) at the severe stage. Electrophoretic patterns showed that asthmatic bronchitis disease at mild and severe stages were physiologically similar to control by 54.5 and 75.6% (protein), 73.1 and 41.6% (lipid moiety), 66.4 and 30.6% (calcium moiety), respectively. As regards to electrophoretic isoenzymes, the disease at mild and severe stages were similar to control by 95.2 and 35.4% (catalase (CAT)), 40.1 and 50.5% (peroxidase (POX)), 67.9 and 69.6% (α-esterase (α-EST)), 83.1 and 73.1% (β-esterase (β-EST)), respectively.ConclusionThe native electrophoretic patterns used as diagnostic tool for determining the stage at which the patients with asthmatic bronchitis exist.
Highlights
Asthmatic bronchitis is a chronic allergic airway disease involved by multiple cells (Nahori et al 2001; Han et al 2016)
The native electrophoretic patterns used as diagnostic tool for determining the stage at which the patients with asthmatic bronchitis exist
The blood gases showed no differences recorded significantly in asthmatic bronchitis patients at both of mild and severe stages when compared to healthy individuals
Summary
Asthmatic bronchitis is a chronic allergic airway disease involved by multiple cells (Nahori et al 2001; Han et al 2016) It may occur in a large number of patients who smoke cigarettes heavily. It is well known that the chronic mucous hypersecretion and airway hyperreactivity are considered as the most common features in the patients who suffer from this disease (Griffith and Garcia 1988). It is usually associated with major chronic-specific symptoms like cough and dyspnea (Molyneux et al 2006; Yildiz and Igde 2018). This study was designed to reveal relation of the different electrophoretic patterns to impairment of the lung functions in patients with asthmatic bronchitis
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