Abstract
A pandemic caused by the novel coronavirus (SARS-CoV-2 or COVID-19) began in December 2019 in Wuhan, China, and the number of newly reported cases continues to increase. More than 19.7 million cases have been reported globally and about 728,000 have died as of this writing (10 August 2020). Recently, it has been confirmed that the SARS-CoV-2 main protease (Mpro) enzyme is responsible not only for viral reproduction but also impedes host immune responses. The Mpro provides a highly favorable pharmacological target for the discovery and design of inhibitors. Currently, no specific therapies are available, and investigations into the treatment of COVID-19 are lacking. Therefore, herein, we analyzed the bioactive phytocompounds isolated by gas chromatography–mass spectroscopy (GC-MS) from Tinospora crispa as potential COVID-19 Mpro inhibitors, using molecular docking study. Our analyses unveiled that the top nine hits might serve as potential anti-SARS-CoV-2 lead molecules, with three of them exerting biological activity and warranting further optimization and drug development to combat COVID-19.
Highlights
In late December 2019, Severe Acute Respiratory Disorder Coronavirus 2 (SARS-CoV-2) became an outbreak in China and spread to other countries
Medicinal plants are endowed with plenty of phytocompounds, and since ancient times, plant-derived compounds have been used for treatment in numerous diseases [15,37,38]
The isolated compounds obtained from the methanol extract of T. crispa were investigated in silico, which concluded that some selective compounds are potentially enough to alter the activity of the SARS-CoV-2 main protease (Mpro) enzyme
Summary
In late December 2019, Severe Acute Respiratory Disorder Coronavirus 2 (SARS-CoV-2) became an outbreak in China and spread to other countries. Infected persons exhibit pneumonia indications, progressing to severe acute respiratory disorder. In January 2020, it was confirmed that an unknown sort of coronavirus named SARS-CoV-2 (formerly named as 2019-nCoV) had come out. On February 11, 2020, the World Health Organization (WHO) named the Wuhan pneumonia as Coronavirus Disease-2019. (COVID-19) and declared this infectious disease to be a global pandemic. Certain animals, including mammals, reptiles, and birds prone to this infectious disease caused by the virus are deadly, while there have been several deaths by respiratory contamination transmitted from animal to human transmitted to humans [1,2]. The virus, known as coronavirus, a single RNA-stranded virus, belongs to the Coronaviridae family
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
