Abstract
The effects of dl-N-propargkl ampheta-mine on monoamine oxidase in rat brain have been studied. It was found that i.p. injection of this compound produced a marked stereotyped response. It was also found to potentiate the stereotypy produced by amphetamine. Subsequent examination of monamine oxidase activity in the brains of the animals showed substantial inhibition of the B form of this enzyme (as judged by 2-phenylethylamine oxidation) but no effect on the A form. The optical isomers of N-propargyl amphetamine have been prepared and their inhibitory activityin vitro against monamine oxidase in rat liver mitochondria has been assessed. The l-isomer was found to be a better inhibitor than the d-isomer.
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