Abstract
Culinary condiments have been used for centuries to treat several types of ailments. Four ethanolic lipid fractions including Nigella sativa, Foeniculum vulgare, Laurus nobilis, and Coriandrum sativum were selected to assess their antimicrobial potential alone and combined with antibiotics. Antibacterial activity was determined by various conventional procedures such as aromatogram test, well diffusion, macro-broth dilution, disc diffusion assay. The tested lipid fractions exhibited antibacterial activity against selected bacterial strains. Antibacterial activity of lipid fractions was also seen within two hours of incubation. These lipid fractions attacked the cell wall i.e. the penetrability of bacterial cell and hence intracellular contents released in the environment which was detected at 260 nm of absorbance and verified via scanning electron microscopy. Antagonistic effect was mostly found by the combination of antibiotics and lipid fractions. Though, synergistic effect was obtained with beta-lactam drugs when combined with lipid fraction of Laurus nobilis. Hence the lipid fractions may be used to treat various communicable diseases. However antagonistic outcomes of the combinations suggested that herbal and allopathic therapies should not consume concurrently.
Highlights
Lipid fractions (LFs) have been utilized for a considerable length of time for the treatment of human beings
These lipid fractions attacked the cell wall i.e. the penetrability of bacterial cell and intracellular contents released in the environment which was detected at 260 nm of absorbance and verified via scanning electron microscopy
While moderate antibacterial activity showed by LF of LE against all the tested bacterial isolates
Summary
Lipid fractions (LFs) have been utilized for a considerable length of time for the treatment of human beings. They produce positive therapeutic, restorative and mental impact on human body. Studies affirmed that commensal bacteria transfer resistance genes to other bacteria faster than pathogenic microbes [2] [3]. Such commensal species for example Citrobacter can affect the respiratory tract, enter the circulatory system, upset digestion and cause gastric-related problems like gastroenteritis caused by verotoxigenic C. freundii recouped from butter parsley sandwiches [4] [5]. Most of the bacteria of Enterobacteriaceae family have enzyme named histidine decarboxylase responsible for histamine production which mounts various allergic responses [8] [9]
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