Abstract
The first biocatalytic asymmetric Henry reaction has been described. Addition of nitroalkanes 2 to aldehydes 1 in the presence of hydroxynitrile lyase from Hevea brasiliensis (HbHNL) gives nitroalcohols 3 in good yields, enantioselectivities, and diastereoselectivities. Both aromatic and aliphatic aldehydes can be used. Furthermore, mechanistic investigations based on molecular modeling as well as kinetic experiments are provided.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
