BioBERT and Similar Approaches for Relation Extraction.

Abstract

In biomedicine, facts about relations between entities (disease, gene, drug, etc.) are hidden in the large trove of 30million scientific publications. The curated information is proven to play an important role in various applications such as drug repurposing and precision medicine. Recently, due to the advancement in deep learning a transformer architecture named BERT (Bidirectional Encoder Representations from Transformers) has been proposed. This pretrained language model trained using the Books Corpus with 800M words and English Wikipedia with 2500M words reported state of the art results in various NLP (Natural Language Processing) tasks including relation extraction. It is a widely accepted notion that due to the word distribution shift, general domain models exhibit poor performance in information extraction tasks of the biomedical domain. Due to this, an architecture is later adapted to the biomedical domain by training the language models using 28million scientific literatures from PubMed and PubMed central. This chapter presents a protocol for relation extraction using BERT by discussing state-of-the-art for BERT versions in the biomedical domain such as BioBERT. The protocol emphasis on general BERT architecture, pretraining and fine tuning, leveraging biomedical information, and finally a knowledge graph infusion to the BERT model layer.