Abstract

India is declared as the diabetic capital of the world. Clinically well-annotated blood samples will advance diabetes research for better diagnostic and treatment methods. Building a disease-specific biobank with high-quality peripheral blood mononuclear cells (PBMCs) and clinical follow-up data system will serve as a good platform for clinical research in diabetes. Processing and storage of high-quality biospecimen for translational research in diabetes demand the implementation of good clinical laboratory practices. “Certification or accreditation programs” that improve biorepository processes and frameworks are lacking in Indian context. To sustain and translate the research into clinical practice, good governance of the biobank and financial resources is required. For ethical issues related to health needs of the people and participants in the research, issues related to research process, translational research, and commercialization, data sharing should be addressed. For India to be an innovation and sustainable country Indian government is supporting translational research facilities, including biobanks. India has developed biobanks for various diseases; however, diabetes-specific research biorepository is lacking. Given the dangers of diabetic burden, India should set up a diabetes disease-specific repository learning from the global organizations and customize to the needs of Indian context. It is important to have private agencies get involved to develop biobanks and future research as there are commercial goals to translate research into practice. New technologies of specimen storing and preservation, data management, and data sharing should be adopted for developing cost-effective long-standing disease-specific population biobank in India.

Highlights

  • Diabetes is a major, common, costly, yet preventable disease with early detection, lifestyle modifications, and therapy

  • Building a disease-specific biobank with highquality peripheral blood mononuclear cells (PBMCs) and clinical follow-up data system will serve as a good platform for clinical research in diabetes

  • Processing and storage of high-quality biospecimen for translational research in diabetes demand the implementation of good clinical laboratory practices. ‘‘Certification or accreditation programs’’ that improve biorepository processes and frameworks are lacking in Indian context

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Summary

Introduction

Common, costly, yet preventable disease with early detection, lifestyle modifications, and therapy. Types of Biobanks in Diabetes Research A biobank is a type of biorepository that collects, processes, preserves, and stores high-quality biospecimen (of microbes, plants, animals, including humans) and its associated data for use in research and clinical care. Requirements to Build a Biospecimen Repository A diabetes disease-specific biobank will serve as a resource for investigating many clinically relevant research questions. Significant ethical obligations are associated with the use of data and biospecimen; issues like who owns the stored biospecimen as substantial property, concerns of the participants and maintaining autonomy, commercial gains, and proper utilization of the contributed biospecimen are essential to getting to the kinds of advances in science to promote the health care that we need.

Brain disorders Cancer Cancer
Blood storage of urine and blood samples and isolated DNA
Abbreviations Used

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