Abstract
Aim of the current research work to conduct bio availability of Nicardipine Hydrochloride S-SMEDDS in rats, compare with pure drug and Marketed Formulation. Study is conducted by using Wistar rats. 3-Groups were divided into Set-A Pure Drug, Set B: Marketed formulation, Set C: Optimized formulation, Total 18 healthy rats were selected, 6 in each group with weight of 300±50g Rats were labeled by numbers. Blood samples were collected from Tail vein method at pre-determined time intervals then blood samples were analyzed by validated HPLC method. S-SMEDDS exhibit cmax at 1429.58±107.40ng/mL, tmax at 0.75Hr, AUC(0-t) at 3042.05±333.35 ng. min/ml and t1/2 at 3.49±0.016 hr. AUC and maximum plasma concentration of the S-SMEDDS is higher than pure Nicardipine Hydrochloride drug and marketed formulation it indicates S-SMEDDS produce more bioavailability than Nicardipine Hydrochloride powder.
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