Abstract
Many in vitro studies have shown that tea catechins had vevarious health beneficial effects. However, inconsistent results between in vitro and in vivo studies or between laboratory tests and epidemical studies are observed. Low bioavailability of tea catechins was an important factor leading to these inconsistencies. Research advances in bioavailability studies involving absorption and metabolic biotransformation of tea catechins were reviewed in the present paper. Related techniques for improving their bioavailability such as nanostructure-based drug delivery system, molecular modification, and co-administration of catechins with other bioactives were also discussed.
Highlights
Increased evidence has expanded the role of green tea from a traditional beverage to a source of bioactive ingredients with many health benefits
Stalmach et al [32,33] reported that when human subjects with an ileostomy μmol of catechins, 70% of the ingested catechins was detected in the ileal fluid during 0–24 h after consumed green tea solution containing 634 μmol of catechins, 70% of the ingested catechins was administration, in which 33% was in the form of parent compounds and 37% was the metabolites detected in the ileal fluid during 0–24 h after administration, in which 33% was in the form of parent with 23 compounds in total
In vitro study shows that chitosan-tripolyphosphate (TPP) nanoparticles improved the stability of epigallocatechin gallate (EGCG) in alkaline solution [66]
Summary
Increased evidence has expanded the role of green tea from a traditional beverage to a source of bioactive ingredients with many health benefits. The systemic availability of EGCG increased at higher doses, possibly due to saturable pre-systemic elimination of orally administered green tea polyphenols (GTPs) [23]. It is obviously not a good idea to use excessive dose of catechins for improving effectiveness. The present paper comprehensively reviews the mechanisms leading to low absorption, poor permeability and less stability of tea catechins and describes the potential for improving the bioavailability of tea catechins through new techniques such as nanoparticle-based delivery systems, structurally modified molecule of catechins, co-administration with other drugs or bioactives. Into a discussion on the bioavailability of catechins, and to provide more thorough insights into the way and mechanism to improve
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
