Abstract
The fundamental pharmacokinetic properties of ADD-3878 were evaluated and the bioavailability of the drug after oral administration was determined in beagle dogs. A pharmacokinetic analysis after intravenous injection of the drug revealed biphasic elimination of the plasma ADD-3878 concentration following a biexponential model with a t 1 2 ,α of 0.27 h and a t 1 2 ,β of 17.11 h. The gastrointestinal absorption of ADD-3878 in solution was significantly faster than those in suspensions. The particle size of ADD-3878 crystals affected both the extent and rate of bioavailability. Furthermore, a significant effect of food on the bioavailability of the drug was observed; the absorption in tablets after food ingestion was approximately double of that in the fasting state. The maximum plasma levels and the areas under the curve at various doses of tablets were proportional to the doses. In a multiple-dose study, there was no unusual accumulation of plasma ADD-3878 concentration.
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