Abstract
Objective To compare the difference in bioavailability of ligusticum wallichii microemulsion and decoction by detecting the concentration of Ferulic acid in rabbit plasma. Methods RP-HPLC was used to detect the concentration of Ferulic acid in rabbits plasma at different times, and software 3p87 was used to analyze the pharmacokinetics parameter. Results The pharmacokinetics parameters of ligusticum wallichii microemulsion and decoction were as follows： AUC0-9=2 123.6 μg/（ml·min）, Cmax=5.086 μg/ml, Tpeak=56.26 min for microemulsion;Decoction：AUC0-9=878.35 μg/（ml·min）, Cmax=2.427μg/ml, Tpeak=128.86 min for decoction, F（%）=241.77. Conclusion Microemulsion of ligusticum wallichii has a higher biological availability and shorter peak time than decoction. Key words: Ligusticum wallichii; Microemulsion; HPLC; Bioavailability
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
