Abstract
<p> This review summarises the recent developments concerning natural products with platelet activating factor (PAF)-related activity. Four in vitro models based on the interaction of PAF with different cell types are discussed with respect to their possibilities and limitations. These assays are suitable for studies of bioassay directed isolation of anti-inflammatory natural products and the identified active compounds represent a variety of biosynthetic origins. </p> <p> The most common method used is thrombocyte aggregation induced by PAF and this review comprises some 50 different compounds studied in the model. The inhibition of PAF biosynthesis can be investigated at two levels and the activity of some 30 natural substances in corresponding assays is presented. Exocytosis induced by PAF (20 compounds) and PAF receptor binding (36 compounds) are summarised using neutrophil models. </p> <p> An application of some of these methods is given for bioactive directed isolation of three different types of compounds originating from the fern Polypodium decumanum Willd. used against psoriasis. </p>
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