Abstract
Ganoderma hainanense, an edible mushroom mainly distributed in Southern China, has long been used as a functional food with considerable health benefits. Bioassay-guided phytochemical research on the fruiting bodies of G. hainanense led to the isolation of 22 lanostane-type triterpenoids, including two new compounds 3-acetyl-ganodermadiol (1) and 3-acetyl-lucidumol B (2). In an in-vitro assay, sixteen out of the twenty-two triterpenoids were found to possess more potent α-glucosidase inhibitory activity than the positive control acarbose. Preliminary structure-activity relationship (SAR) analysis indicated that the side chain structures of these compounds could significantly influence the activity. Results of the present study revealed that lanostane-type triterpenoids with α-glucosidase inhibitory activity may contribute to the hypoglycaemic effects of G. hainanense in the folk usage, and also the potentiality to develop G. hainanense as dietary supplement for glycemic control.
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