Abstract
Liver tissue engineering aims at the reconstruction in vitro of a tissue mimicking as much as possible the organ functions. For the liver, the challenge is very high since this organ is in charge o...
Highlights
Liver tissue engineering aims at the reconstruction in vitro of a tissue mimicking as much as possible the organ functions
Within an intermediate range of 2–3 kPa, we observed that cells successfully reorganized in 3D structure filling alginate pores (Figure 2)
Perfusion was possible with limited pressure drops and cells’ functions could be maintained for several days
Summary
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING 2019, VOL. We propose several bioinspired approaches at different scales to offer to the cells the ‘best’ biomechanical environment. This means that both artificial matrix and bioreactor can be designed to meet physiological conditions encountered in the native liver
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