Abstract
An optimized, simple, accurate method is developed to quantify Tizanidine in bulk and pharmaceutical formulation using the RP – HPLC method using a silica ODS C18 column with the aid of MeOH: H2O:0.01M orthophosphoric acid ( 95:4:1 v/v/v) as a mobile phase and deduced at 320nm. The RT value was found to be 2.274 with a resolution of 1.167 respectively. The spiking studies of Tizanidine in human plasma were also carried out. The linearity studies of TZA (10 -50 mcg/mL) were found to be R2 =0.99979 (API) and R2 = 0.8155 respectively. The suggested study was validated as per the criteria of the ICH guidelines. The proposed study could be easily adopted in the pharmaceutical industry for performing quantitative analyses
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