Abstract
AbstractA bioadhesive tablet of metronidazole has been developed for oral or vaginal administration. The bioadhesive component is poly(acrylic acid) (Carbopol 934), and the matrix component is hydroxypropyl methylcellulose (HPMC K4M). The influence of the test medium was investigated in order to determine the adhesion of the tablet during routine use by the various routes. The parameter retained to evaluate adhesion was the adhesion work on a biological tissue. The factors whose influence was investigated were pH, ionic force and nature of cations, and type of biological substrate
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