Abstract
Local drug delivery is an effective strategy for achieving direct and instant therapeutic effects. Current clinical treatments have fallen short and are limited by traditional technologies. Bioadhesive nanoparticles (NPs), however, may be a promising carrier for optimized local drug delivery, offering prolonged drug retention time and steadily maintained therapeutic concentrations. In addition, the possibility of clinical applications of this platform are abundant, as most polymers used for bioadhesion are both biodegradable and biocompatible. This review highlights the major advances in the investigations of polymer-based bioadhesive nanoparticles and their innumerable applications in local drug delivery.
Highlights
Systemic drug delivery is an advantageous delivery route due to its accelerated onset of action, it is often difficult to maintain the required local drug concentration. administering higher dosages is often not a feasible solution coupled with the restriction of limited extravasation from the bloodstream into the target sites
Bioadhesive nanoparticles have been explored for local drug delivery action and can be divided into natural biopolymer-based and synthetic or semi-synthetic polymer-based [7,8]
Khuthat the amount of Helicobacter pylori (H. pylori) in a C57BL/6 mouse model was signifitoryanskaya et al constructed mucoadhesive films based on NPs comprised of PAA and cantly decreased following oral administration of ethyl cellulose (EC) NPs encapsulating methylcellulose (MC)
Summary
Systemic drug delivery is an advantageous delivery route due to its accelerated onset of action, it is often difficult to maintain the required local drug concentration. Administering higher dosages is often not a feasible solution coupled with the restriction of limited extravasation from the bloodstream into the target sites These factors can lead to higher toxic effect and adverse side effects. Bioadhesive nanoparticles have been explored for local drug delivery action and can be divided into natural biopolymer-based and synthetic or semi-synthetic polymer-based [7,8]. Synthetic or semi-synthetic polymer-based systems, deliver optimal adhesion in comparison to natural biopolymers but may induce increased chronic inflammation or higher cytotoxicity from potentially toxic degradation products (Figure 1) [7,8]. The nanotechnology approach through nanoparticles (NPs), cuses adhesive on the key polymers exhibit bioadhesive properties, its related applications, may overcome limitations in bioadhesion. Polyglycerol; PAA: Bioadhesive can prolong drug retention time but can encourage
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