Abstract
Bioadhesive controlled release systems for the delivery of metronidazole were prepared by compression of hydroxypropyl methylcellulose with poly(acrylic acid), which served as the bioactive adhesive compound. The release behavior of systems containing 50 wt% metronidazole and various amounts of the two polymers was found to be non-Fickian. The bioadhesive strength of the bond formed between surface-preswollen systems and the sublingual bovine mucus was determined by novel tensile experiments and it was found to be dependent on the poly( acrylic acid) content.
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