Abstract
Novel bioadhesive controlled release tablets were prepared from poly (acrylic acid) and hydroxypropyl methylcellulose. Their bioadhesive behavior was studied in a modified tensile tester in contact with bovine sublingual mucus, and the force-elongation behavior was measured up to the breakpoint. The work of adhesion was calculated and related to bioadhesive characteristics of the tablets. It was found that the bioadhesive bond strength between these tablets and the bovine mucus was a monotonically increasing function of their poly (acrylic acid) content. The bioadhesive results were analyzed in terms of a new theoretical framework based on the fracture and interpenetration (diffusion) theories of bioadhesion. Important molecular parameters were calculated and new bioadhesive correlations were verified.
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