Abstract
Ethanol extract (EE) from Periplaneta americana (PA) is the main ingredient of Kangfuxin, which is a popular traditional chinese medicine (TCM) and has long been used for the clinical treatment of burns, wounds and ulcers. We compared the wound-healing activities of three extracts of PA using cutaneous wound-healing in mice as the bioactivity model. These three extracts were EE, total polysaccharide and total protein. We also tracked bioactive fractions in the EE by organic reagent extraction, column chromatography and HPLC. Seven compounds were successfully identified from the water elution fraction of the EE of PA using UPLC-MS. Among these compounds, four compounds (P2, P3, P4, P5(1)) were first reported in PA. Some of these compounds have been previously reported to have various pharmacological activities that could contribute to the high wound-healing activity of PA.
Highlights
Wound healing is a complex biological process including three classic stages: inflammation, new tissue formation and remodeling [1]
We found that the healing rates of the ethanol extract (EE)-treated group were the highest at each time interval compared to the TPS, total protein protein (TP) and negative control (NC) groups (Figure 1b)
The results indicated that highly polar constituents predominant in the EE may contribute to the wound-healing activity
Summary
Wound healing is a complex biological process including three classic stages: inflammation, new tissue formation and remodeling [1]. Any aberrancies at each stage can lead to delayed wound healing. Many synthetic drugs and artificial skins are used for wound healing, but they are expensive and readily cause allergic reactions in sensitive people [2,3,4]. There is a real need for an alternative to synthetic wound-healing products. Natural products are the most reliable and successful sources of drug leads. Insects have been increasingly used as effective bioactive products and as they are one of the most diverse taxa of living organisms can provide a considerable resource of potential alternatives [5]. The potential for insect constituents, such as cockroaches, to enhance natural wound healing is a important research avenue
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