Bioactivity evaluation and phytochemical screening of Euphorbia helioscopia and Rumex dentatus

Rana Muhammad Aadil,Shomaila Mehmood,Muhammad Issa Khan,Fatima Syed

doi:10.1590/fst.66721

Abstract

Euphorbia helioscopia and Rumex dentatus are two essential medicinal plants that are widely used in traditional medicines against various illnesses. The present research was focused to confirm and validate the antibacterial, antifungal and antitumor activities of both plants. The antimicrobial activities were investigated against different bacterial and fungal strains. The in vitro antioxidant activities were confirmed against DPPH, hydroxyl and superoxide free radicals using ascorbic acid (Vc) as a standard. The results indicated that the increase in percentage scavenging activity is due to the increase in concentration of both plant extracts from 50-500 µg/mL. Moreover, the percentage tumor inhibition of both plant extracts was confirmed by potato disc method using dimethylsulfoxide (DMSO) as a negative control. The higher percentage of tumor inhibition was observed for water and ethanolic extract in case of E. helioscopia and R. dentatus, respectively.

Highlights

There are about 6,000 higher plant species in Pakistan and about 10% of that has medical value
Our results indicated that the zone of inhibition was considerably affected by the plant extracts
In vitro antioxidant, and antitumor activities of both plants in different solvents according to the increasing polarity

Summary

Introduction

There are about 6,000 higher plant species in Pakistan and about 10% of that has medical value. Medicinal plants are key sources of raw materials for both modern and traditional medicines and have been used to cure human ailments for many years. These medications serve as an important source of new bioactive compounds, such as antimicrobial agents (Batool et al, 2018). Secondary metabolites are categorized as glycosides, alkaloids, phenolic compounds, terpenoids, tannins, volatile oils, saponins, resins, steroids, etc. Many of these secondary metabolites which are possibly true isolates, mixtures and chemically modified derivatives of plants are commercially significant and are used in flavoring, fragrances, and pharmaceutical formulations, worldwide (Padalia, 2012)

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