Abstract
Electrospinning is useful for fabricating nanofibrous structure with different composition and morphologies. It offers great advantages through its geometrical structure and biomimetic property, which can provide a suitable environmental site for cell growth. The fiber diameter is entangled by the concentration of PCL with some adjustment of parameters during electrospinning process. PCL with lower concentration had bead structure while higher concentration had smooth fiber. The incorporation of nanoparticle hydroxyapatite (nHA) into poly(ɛ-caprolactone) fiber was studied. The fiber diameter of PCL was increased with the addition of nHA. Composition of fiber at lower concentrations of PCL and nHA into the polymer produced fiber with a homogenous distribution of nHA in PCL fiber with less agglomeration. The immersion of PCL/nHA fiber in simulated body fluid (SBF) had bone-like apatite layer on its surface while PCL showed no results. PCL/nHA showed high water uptake and had improved wettability compared to PCL alone, suggesting that PCL/nHA fibers were more hydrophilic than PCL fiber.
Highlights
Bone is a nanostructured biomaterial with unique biological and mechanical properties
Surface roughness had influence on this property [19, 20]. These results indicated that PCL/nanoparticle hydroxyapatite (nHA) fibers had better hydrophilicity
The results showed PCL/nHA exhibits better hydrophilicity than PCL fiber
Summary
Bone is a nanostructured biomaterial with unique biological and mechanical properties. It consists of inorganic hydroxyapatite crystal, organic type I collagen fibers, and other proteins [1]. At some time bone may damage and lose its function because of disease or accident. There is a clinical need for the replacement of the damaged bone. Current trend in clinical practice to overcome the problem is tissue engineering. The purpose of tissue engineering is to regenerate and restore damaged tissue with the combinations of biomaterials, cells, and bioactive agents [2]. Commonly biodegradable and biocompatible scaffold is used to replace the defect providing a platform for cell function, adhesion, and transplantation
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