Abstract
Abstract The study demonstrated the in vitro and in vivo anti-hyperchoeterolemic activity of purified fraction of fermentation extract of endophytic fungus Diaporthe arengae TATW2 isolated from Terminalia arjuna Roxb. (Combretaceae). In vitro anti-hypercholesterolemic activity was carried out using human red blood cells (hRBCs) of healthy and hypercholesterolemic donors. Bioactive fraction of the crude extract was obtained using activity guided fractionation followed by Thin-Layer Chromatography (TLC). In vivo efficacy studies of this isolated compound were carried out using albino Wistar rats. After 24 h incubation of whole blood as well as isolated erythrocytes from hypercholesterolemic donors with 100 µg/mL of extract of TATW 2, the concentration of RBC membrane cholesterol was found to be reduced significantly (P
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