Abstract
In the present study, we screened the biological activity of extracts from the marine sponge Halichondria panicea collected in the Arabian Sea. Crude toxin was obtained by methanol, chloroform-methanol (2:1) and aqueous extraction. Subsequently, the protein concentration of each crude extract was determined. The impact of both sponge methanolic and aqueous extracts was found to increase activities of Na+-K+ ATP-ase and Mg++ ATP-ase. In the case of chloroform-methanol extract, higher concentrations increased acetylcholine esterase (AchE) activity. The methanolic and chloroform-methanol extracts exhibited hemolytic activity on chicken and human erythrocytes, whereas the aqueous extract failed to do so. Methanol and aqueous extracts produced an immunostimulating effect and all extracts revealed angiogenic activity. The aqueous extract yielded nine bands by SDS-PAGE on 12% gel.
Highlights
Sponges are simple multicellular sessile animals with no true tissue layers or organs (1)
In the present study, we screened the biological activity of extracts from the marine sponge Halichondria panicea collected in the Arabian Sea
The present study comprises an initial effort to assess the bioactivity of secondary metabolites from the marine subtidal sponge Halichondria panicea (Demospongiae class, Halichondrida order, Halichondriidae famaily)
Summary
Sponges are simple multicellular sessile animals with no true tissue layers or organs (1). They populate tropical and subtropical benthic marine habitats but are found at higher latitudes and even in freshwater lakes and streams (2). Over 60% of potentially useful bioactive compounds discovered so far from living organisms have been obtained from marine fauna, 70% of which comes from sponges (4). The sponge class Demospongiae is known for producing the largest number and diversity of secondary metabolites isolated from marine invertebrates (6). The present study comprises an initial effort to assess the bioactivity of secondary metabolites from the marine subtidal sponge Halichondria panicea (Demospongiae class, Halichondrida order, Halichondriidae famaily)
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