Bioactive xanthones from whole plants of Gentianella acuta

Abstract

ObjectiveTo study the constituents from the whole plants of Gentianella acuta and their biological activities. MethodsThe compounds were isolated by multiple chromatographic methods and the structures of mentioned isolates were determined by routine NMR experiments and chemical methods. ResultsA phytochemical investigation to obtain intestine motility inhibitor resulted in the isolation of one new xanthone glycoside, gentixanthonoside A (1), along with nine tetrahydroxanthones, 1,3,5R,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (2), 1,3,5S,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone (3), amarellin E (4), amarellin F (5), swertiachoside B (6), amarellin D (7), amarellin C (8), amarellin A (9), and amarellin B (10) from the whole plants of G. acuta. ConclusionCompounds 2–10 showed significant reduce effects on contraction tension at 40 µM.