Abstract
Recent studies on signal transduction pathways have indicated various promising molecular targets for cancer treatment. Along these lines, a hyphae formation inhibition (HFI) assay [1] in Streptomyces 85E was adopted to rapidly screen and identify protein phosphorylation inhibitors. The organic extract of the marine sponge Fasciospongia sp. was found to significantly inhibit activity in the HFI assay. Bioassay-guided fractionation of this organic extract yielded two new unusual sesterterpene alkaloids (1 and 2), and a new sesterterpene sulfate (3), along with four known compounds. The structures were elucidated on the basis of spectroscopic analysis. Compounds 1-7 exhibited significant inhibitory activities in the HFI assay. These compounds were further evaluated in cytotoxicity assays with various cancer cell lines as described previously [2]. The structure elucidation and biological activities of these compounds is presented.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
