Abstract
A continuing chemical investigation of the ethyl acetate (EtOAc) extract of a reef soft coral Sinularia brassica, which was cultured in a tank, afforded four new steroids with methyl ester groups, sinubrasones A–D (1–4) for the first time. In particular, 1 possesses a β-d-xylopyranose. The structures of the new compounds were elucidated on the basis of spectroscopic analyses. The cytotoxicities of compounds 1–4 against the proliferation of a limited panel of cancer cell lines were assayed. The anti-inflammatory activities of these new compounds 1–4 were also evaluated by measuring their ability to suppress superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils. Compounds 2 and 3 were shown to exhibit significant cytotoxicity, and compounds 3 and 4 were also found to display attracting anti-inflammatory activities.
Highlights
Soft corals of the genus Sinularia have yielded series of natural products of differing chemical types [1]
A reef reef soft softcoral coralS.S.brassica brassicafurther further cultured a tank collected by hand a cultivation cultured in in a tank waswas collected by hand fromfrom a cultivation pool pool of at the Aquarium, Taiwan, in
As previous studies revealed that steroids from soft corals might possess attracting biological activities [29,30,31,32,33], we further evaluated the biological activities of these isolated steroids
Summary
Soft corals of the genus Sinularia have yielded series of natural products of differing chemical types [1]. Many of these compounds have been shown to exhibit interesting bioactivities, such as cytotoxic [2,3,4,5,6,7,8], antifouling [9], and anti-inflammatory [10,11,12,13,14,15,16,17,18] activities. Previous chemical investigation of the wild-type soft coral Sinularia brassica (May 1898) has led to the isolation of only two new steroids from this marine organism [19]. We report the isolation, structure elucidation and biological activities of these compounds
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