Abstract
Five new compounds 15R-17,18-dehydroxantholipin (1), (3E,5E,7E)-3-methyldeca-3,5,7-triene-2,9-dione (2) and qinlactone A–C (3–5) were identified from mangrove Streptomyces qinglanensis 172205 with “genetic dereplication,” which deleted the highly expressed secondary metabolite-enterocin biosynthetic gene cluster. The chemical structures were established by spectroscopic methods, and the absolute configurations were determined by electronic circular dichroism (ECD). Compound 1 exhibited strong anti-microbial and antiproliferative bioactivities, while compounds 2–4 showed weak antiproliferative activities.
Highlights
Microbial natural products are an important source of drug lead
172205∆enc was(polymerase obtained by chain the enterocin biosynthetic gene(Supplementary cluster deletion
We identified five new compounds with bioactivities from mangrove Streptomyces qinglanensis 172205 with “genetic dereplication.”
Summary
Microbial natural products are an important source of drug lead. Mangrove streptomycetes were reported as a potential source of plenty of antiproliferative or anti-microbial chemicals with novel structures [1]. The bioinformatics of available genome information from microorganisms breaks the bottleneck of traditional natural product discovery to a certain extent, and secondary metabolites isolation guided by genome sequence has increasingly become a research frontier [2]. Due to complexity profiles of secondary metabolites including intermediates, a strategy named “genetic dereplication” was developed to simplify the profiles by eliminating the major known secondary metabolites’ biosynthetic pathway, so that more detecting other novel compounds and/or reversing the precursor pools for other low expressed pathways in the microorganisms [8]
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