Abstract
Abstract The robust [Zn4O(3,5-dimethyl-4-carboxypyrazolato)3] ([Zn4O(dmcapz)3]) 3D metal-organic framework (MOF) is studied as a suitable platform for the controlled release of bioactive molecules. With this aim, a simple ball milling technique is used to efficiently encapsulate the model drugs 5-fluorouracil, caffeine, para-aminobenzoic acid, and benzocaine. Both computational and experimental studies confirm the suitability of [Zn4O(dmcapz)3] to incorporate high loadings of the studied bioactive molecules. The results show that the physicochemical properties of bioactive molecule effects on the loading efficiency on the MOF structure. The controlled release of the bioactive molecules from drug@[Zn4O(dmcapz)3] is studied under simulated cutaneous conditions to prove its suitability as topical drug delivery systems. In this regard, 5-fluorouracil@[Zn4O(dmcapz)3] system is incorporated in the preoxidized cellulosic fabric to demonstrate their possible application for antibacterial treatment and skin cancer therapy. The results show that the 5-fluorouracil@[Zn4O(dmcapz)3] loaded cellulosic fabrics exhibit potentially significant anticancer and antibacterial activities.
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