Abstract
Mariana Trench sediments are enriched in microorganisms, however, the structures and bioactivities of their secondary metabolites are not very known. In this study, a fungus Penicillium sp. SY2107 was isolated from a sample of Mariana Trench sediment collected at a depth of 11000 m and an extract prepared from the culture of this fungus in rice medium showed antimicrobial activities. Chemical investigation on this active extract led to the isolation of 16 compounds, including one novel meroterpenoid, named andrastone C. Structure of the new compound was elucidated based on high-resolution electrospray ionization mass spectroscopy (HRESIMS) data, extensive nuclear magnetic resonance (NMR) spectroscopic analyses and a single crystal X-ray diffraction. The crystal structure of a known meroterpenoid andrastone B was also reported in this study. Both andrastones B and C exhibited antimicrobial activities against methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli, and Candida albicans with minimum inhibitory concentration (MIC) values in a range from 6 to 13 μg/mL.
Highlights
Marine natural products are important sources for the discovery of novel bioactive agents and drug leads [1,2,3,4,5]
The vast majority of these reported marine natural products are obtained from the shallow-water samples and only circa 2% are isolated from the deep-sea organisms [6,7,8]
The extract prepared from the culture of this isolated hadal in rice medium showed activities in inhibiting the growth of methicillin-resistant Staphylococcus aureus fungus in rice medium showed activities in inhibiting the growth of methicillin-resistant (MRSA), Escherichia coli, and Candida albicans
Summary
Marine natural products are important sources for the discovery of novel bioactive agents and drug leads [1,2,3,4,5]. Mariana Trench sediments are enriched in microorganisms [15,16], the structures and and bioactivities of their secondary metabolites are not very known and need to be explored. The extract prepared from the culture of this isolated hadal in rice medium showed activities in inhibiting the growth of methicillin-resistant Staphylococcus aureus fungus in rice medium showed activities in inhibiting the growth of methicillin-resistant (MRSA), Escherichia coli, and Candida albicans Chemical investigation on this active extract resulted. Staphylococcus aureus (MRSA), Escherichia coli, and Candida albicans Chemical investigation on this in the isolation of 16 compounds (1–16, Figure 1), including one novel antimicrobial meroterpenoid, active extract resulted in the isolation of 16 compounds (1–16, Figure 1), including one novel named andrastone C (1).
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