Abstract
A new hydroanthraquinone, nigrosporone A (1), and a new naturally occurring nigrosporone B (2), together with eleven known compounds, were isolated from an endophytic fungus, Nigrospora sp. BCC 47789. The structure of nigrosporone A was confirmed by X-ray crystallographic analysis. The absolute configurations of nigrosporone B were determined by the modified Mosher’s method. Nigrosporone B exhibited a broad range of biological activities including antimalarial, antitubercular, antibacterial and cytotoxic activities, while nigrosporone A and Fusaquinon A showed only cytotoxic activity.
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