Abstract
Eight new diarylheptanoids, coriandralpinins A–H (1–8), were isolated from the rhizomes of Alpinia coriandriodora, an edible plant of the ginger family. Their structures, including the absolute configurations, were established by extensive spectroscopic analysis and ECD calculations. Compounds 1–8 have a 1,5-O-bridged diarylheptanoid structure featuring polyoxygenated aryl units. When evaluated for intracellular antioxidant activity using t-BHP stressed RAW264.7 macrophages, all these compounds scavenged reactive oxygen species (ROS) in a concentration-dependent manner. Compounds 3 and 5 also showed inhibitory activity against NO release in LPS-induced RAW 264.7 cells. Six known flavonols, 7,4′-di-O-methylkaempferol, 7-O-methylquercetin, 7,4′-di-O-methylquercetin, 7,3′,4′-tri-O- methylquercetin, kaempferol 3-O-β-d-(6-O-α-l-rhamnopyranosyl)glucopyranoside, and 3-O-β-d-glucopyranuronosylquercetin were also isolated and characterized from the rhizomes.
Highlights
Metabolism of oxygen is crucial to life for the production of energy to support biological process
Plants of the genus Alpinia are rich in diarylheptanoids, sesquiterpenoids, and monoterpenes, many of which possess antioxidant [15, 16], anti-inflammatory [17], hepatoprotective [18], and anticancer activities [19, 20]
We present the isolation, characterization, and biological
Summary
Metabolism of oxygen is crucial to life for the production of energy to support biological process. As a consequence of the aerobic metabolism, reactive oxygen species (ROS) are continuously generated in all living organisms, Xiao-Li Cheng, Han-Xiang Li, and Juan Chen have contributed to this work. As part of our going effort to isolate and identify antioxidant and anti-inflammatory compounds from edible and medicinal plants, our attention was drawn to Alpinia coriandriodora D. Plants of the genus Alpinia are rich in diarylheptanoids, sesquiterpenoids, and monoterpenes, many of which possess antioxidant [15, 16], anti-inflammatory [17], hepatoprotective [18], and anticancer activities [19, 20]. We present the isolation, characterization, and biological.
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