Abstract
Abstract From an acid hydrolysate of the crude saponins of Gynostemma pentaphyllum , three triterpenes, including a new compound (23 S )-3 β -hydroxydammar-20,24-dien-21-oic acid 21,23-lactone ( 1 ) and two known aglycons (20 S , 23 R )-3 β ,20 β -dihydroxydamma-24-dien-21-oic acid 21,23-lactone ( 2 ) and (20 S , 24 S )-20,24-epoxydammarane-3 β ,12 β ,25-triol ( 3 ), were isolated. Their structures were established on the basis of extensive spectral evidence (HR-ESI-MS, IR, 1D and 2D-NMR experiments). In bioactive assays in vitro , compound 1 was found to have potent cytotoxicity against the human breast cancer cells MDA-MB-435, whereas compounds 2 and 3 exhibited modest inhibitory activity toward porcine pancreatic lipase. The results indicated that acid treatment of G. pentaphyllum extract could produce diverse structures with interesting bioactivity.
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