Bioactive Constituents from Chinese Natural Medicines. XXXI. Hepatoprotective Principles from Sinocrassula indica: Structures of Sinocrassosides A8, A9, A10, A11, and A12

Abstract

-The methanolic extract from the whole plant of Sinocrassula indica (Crassulaceae) was found to show hepatoprotective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. From the methanolic extract, five new acylated flavonol glycosides, sinocrassosides A 8 (1), A 9 (2), A 10 (3), An (4), and A 12 (5), were isolated together with 25 compounds. The structures of 1-5 were elucidated on the basis of chemical and physicochemical evidence. Among the isolated compounds, sinocrassosides A 1 (6), A 2 (7), and B 2 (14) were found to show potent hepatoprotective effect.