Bioactive compounds of the Ubá mango juice decrease inflammation and hepatic steatosis in obese Wistar rats

Abstract

Obesity is a serious epidemic pathology whose dangerous visceral fat accumulation initiates nonalcoholic fatty liver disease. This study evaluated the effect of the bioactive compounds of the control and peel extract enriched Ubá mango juices on hepatic steatosis associated with inflammation in obese Wistar rats. The biometry, total antioxidant capacity (TAC), adiponectin and resistin, as well as histomorphology of the hepatic tissue were determined in four experimental groups: normal control (AIN‐93M), obese control (HFD), a group with obese rats plus control Ubá mango juice (MHFD) and other with antioxidant enriched Ubá mango juice (HMHFD). Juices were good sources of the β‐carotene, presented high concentration of mangiferin and contributed to decrease the liver weight in animals. Total antioxidant capacity was higher in a group fed with control Ubá mango juice and resistin concentration reduced in both test groups intake Ubá mango juices became similar to normal control. In addition, the percentages of fat vesicles and inflammatory infiltrate in the liver was higher to the animals that intake HFD, and both juices reduced these parameters. In conclusion, the control and enriched Ubá mango juices presented high content 408 of vitamins and mangiferin, with anti‐inflammatory and antioxidant effects, which 409 improved biometric measures, cytokines concentration and was beneficial for obese 410 Wistar rats with adiposity and inflammation in the liver. Therefore, the Ubá mango has 411 potential as a functional food, indicating potential to prevent and combat metabolic risk 412 of obesity, hepatic steatosis and other comorbidities.Support or Funding InformationThe authors would like to thank the Brazilian funding agencies “Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for the financial support with the research, conferences and fellowships in Productivity in Research, Pos‐Doctor's, Masters and scientific innovation.