Abstract
Cancer is a devastating disease that has claimed many lives. Natural bioactive agents from plants are gaining wide attention for their anticancer activities. Several studies have found that natural plant-based bioactive compounds can enhance the efficacy of chemotherapy, and in some cases ameliorate some of the side-effects of drugs used as chemotherapeutic agents. In this paper, we have reviewed the literature on the anticancer effects of four plant-based bioactive compounds namely, curcumin, myricetin, geraniin and tocotrienols (T3) to provide an overview on some of the key findings that are related to this effect. The molecular mechanisms through which the active compounds may exert their anticancer properties in cell and animal-based studies also discussed.
Highlights
Cancer is one of the leading causes of death in the world
For this review, published papers reporting on the anticancer effects of these four bioactive compounds that are indexed in PubMed and/or Google Scholar were selected to be included in this review
Cell-based assays using murine splenocytes showed that geraniin inhibited proliferation of MCF-7 human breast cancer cells with IC50 value of 13.2 μg/mL
Summary
Cancer is one of the leading causes of death in the world. Cancer burden is measured based on cancer incidence and mortality. (v) be insensitive to anti-growth signals [10]; growth signals [10]; and (vi) invade tissue and metastasis [11,12] These attributes allow the cancer and (vi) invade tissue and metastasis [11,12]. These attributes allow the cancer cells to have limitless cells to have limitless growth, prolonged survival and the ability to invade tissues. If these processes growth, prolongedthe survival to invade tissues. Whilst the chemotherapeutic used the treatment of cancer provide temporary relief to the cancer patients and help prolong their life [13,14,15], many of these drugs can provide temporary relief to the cancer patients and help prolong their life [13,14,15], many of these exhibitexhibit side-effects [16,17].[16,17]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
