Abstract
Recently in Nigeria, the use of natural products described as herbal bitter drinks presumed to cure all except death has been on the increase. This paper therefore evaluates the bioactive compounds of three herbal drinks and their concomitant effects on selected hepatic biomarkers in albino Wister rats in Lagos, Nigeria using standard methods. A total of 31 bioactive compounds were positively identified in the three bitter drinks analyzed, Out of which are: Yoyo (5-Hydroxymethylfurfural (6.8%), Coumaran (1.7%), Octamethyl cyclotetrasiloxane ( 4.5%), Squalene(3.2%) - 2,4-Dihydroxy-2,5-dimethyl-3(2H)-furan-3-one(1.7%),3,3-Dimethyl-2butanol(1.1%),2-Hydroxy-2- cyclopenten-1-one (0.7%)). Swedish (Camphor (82.9%), Cinnamic acid (0.2%)). Living (5-Hydroxymethylfurfural 57.4%), Coumaran (1.6%), 3, 4-dihydroxy-3-cyclobutene-1, 2-dione (0.3%). The three bitters had no common bioactive compound betweenthem. Five common bioactive compounds were detected present in both Living and Yoyo bitters. Only 11 (about 35%) of the 31 compounds identified have established and documented pharmacological use. Some of the bioactive components in each of the bitters support the advertised usage of the formulations. The three bitters orally administered to rats from data gathered were not dangerous to the liver over the 40day period of the experiment.Keywords: Yoyo, Swedish, living, hepatic biomarkers
Highlights
In Nigeria, the use of natural products described as herbal bitter drinks presumed to cure all except death has been on the increase
The use of herbals is a common form of alternate medicine that cuts across all spectrum of the Nigerian society
This belief system has thrown up all sorts of alternate medical practitioners including but not limited to herbal practitioners, orthopaedics, etc. One of such fallouts is the large number of different types of herbal mixtures commonly sold in the different Nigerian markets as herbal mixtures (Akinyemi and Dada, 2014; Ogbonnia et al, 2010)
Summary
In Nigeria, the use of natural products described as herbal bitter drinks presumed to cure all except death has been on the increase. Five common bioactive compounds were detected present in both Living and Yoyo bitters. The use of herbals is a common form of alternate medicine that cuts across all spectrum of the Nigerian society. This belief system has thrown up all sorts of alternate medical practitioners including but not limited to herbal practitioners, orthopaedics, etc. One of such fallouts is the large number of different types of herbal mixtures commonly sold in the different Nigerian markets as herbal mixtures (Akinyemi and Dada, 2014; Ogbonnia et al, 2010). This study aims at evaluating the bioactive compounds present in three herbal bitter drinks
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