Bioactive compounds coated 2D scaffold from seeds of Carica papaya for bacterial and parasitic skin infections

Abstract

The plant papaya as Carica papaya L. grows wild and is an economically important seasonal fruit which grows in tropical regions as well as sub-tropical regions. These papaya fruits have some carbohydrates and water, that are low in calories but rich in minerals such as vitamin A, vitamin B and vitamin C. It also constitutes carbohydrates, proteins, proteolytic enzymes (papain and quimiopapain) and alkaloids (carpaine and pseudocarpaine). The special functions of Papaya Seeds Extract (PSE), has been identified as anti-bacterial, anti–fertility, anti-helminthic, anti-amoebic activities and anti-parasitic activities. BITC (benzyl -isothiocyanate) is a bioactive substance present in papaya seeds which has been widely studied among different areas due to its vast application. Like BITC, there are many compounds present in the papaya seeds which are useful in treating bacterial and parasitic skin infections. The present study focus on such un explored compounds namely n-hexadecanoic acid, 1,2 benzenedicarboxylic acid, mono (2-ethylhexyl) ester, 9-octadecenoic acid (z) – 2, 3dihydroxypropyl ester, 9-octadecenoic acid (z) – 2, 3dihydroxypropyl ester and (Z, Z)-Octadeca-5,9-dienic acid, picolinyl ester from the papaya seeds was extracted using methanol as solvent. Purification of compounds was performed for the extraction and identified through GC-MS analysis. From this study, the identified compounds having antiparasitic and antibacterial activity were incorporated into 2D scaffolds which are used for the treatment of skin infections especially psoriasis.