Abstract
Summary The discovery of bioactive compounds underpins many areas of basic biomedical research and constitutes a large part of medicinal chemistry and chemical biology. Synthetic chemistry is now able to provide almost any drug-like molecule imaginable. Therefore, attention has turned to increasing the biological relevance of the compounds to be used in chemical biology and medicinal chemistry research, as well as maximizing their diversity within this large area of chemical space. In this review, we outline key concepts for the design of biologically relevant compound collections by taking inspiration from nature and natural products. We highlight efficient ways to screen the resulting libraries in order to maximize hit rates and the chance of discovering new modes of action. Finally, we discuss state-of-the-art techniques for the identification of molecular targets of hits identified through phenotypic screening approaches.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.