Abstract
In this work, two bioactive glass powders (SBA2 and SBA3) were doped with Cu by means of the ion-exchange technique in aqueous solution. SBA2 glass was subjected to the ion-exchange process by using different Cu salts (copper(II) nitrate, chloride, acetate, and sulphate) and concentrations. Structural (X-ray diffraction-XRD), morphological (Scanning Electron Microscopy-SEM), and compositional (Energy Dispersion Spectrometry-EDS) analyses evidenced the formation of crystalline phases for glasses ion-exchanged in copper(II) nitrate and chloride solutions; while the ion-exchange in copper(II) acetate solutions lead to the incorporation of higher Cu amount than the ion-exchange in copper(II) sulphate solutions. For this reason, the antibacterial test (inhibition halo towards S. aureus) was performed on SBA2 powders ion-exchanged in copper(II) acetate solutions and evidenced a limited antibacterial effect. A second glass composition (SBA3) was developed to allow a greater incorporation of Cu in the glass surface; SBA3 powders were ion-exchanged in copper(II) acetate solutions (0.01 M and 0.05 M). Cu-doped SBA3 powders showed an amorphous structure; morphological analysis evidenced a rougher surface for Cu-doped powders in comparison to the undoped glass. EDS and X-ray photoelectron spectroscopy (XPS) confirmed the Cu introduction as Cu(II) ions. Bioactivity test in simulated body fluid (SBF) showed that Cu introduction did not alter the bioactive behaviour of the glass. Finally, inhibition halo test towards S. aureus evidenced a good antimicrobial effect for glass powders ion-exchanged in copper(II) acetate solutions 0.05 M.
Highlights
The antibacterial test was performed on SBA2 powders ion-exchanged in copper(II)
Was developed to allow a greater incorporation of Cu in the glass surface; SBA3 powders were ion-exchanged in copper(II) acetate solutions (0.01 M and 0.05 M)
Bioactive glasses have been widely investigated in the orthopaedic and dental fields for their ability to chemically bond to living bone through a well-known process, which involves a rapid ion-exchange between glass and surrounding biological fluids, the formation of silica-rich layer, the incorporation of calcium and phosphates, and the crystallization of biologically active hydroxyapatite (HAp) on their surface [1,2,3,4]
Summary
Bioactive glasses have been widely investigated in the orthopaedic and dental fields for their ability to chemically bond to living bone through a well-known process, which involves a rapid ion-exchange between glass and surrounding biological fluids, the formation of silica-rich layer, the incorporation of calcium and phosphates, and the crystallization of biologically active hydroxyapatite (HAp) on their surface [1,2,3,4]. Recent studies report that the release of ionic dissolution products (such as Si4+ , Mg2+ , Ca2+ ) from the bioactive glass surface has stimulating effects on bone formation, playing a key role in the early stages of the bone regeneration processes [8,9,10]. The in vivo colonization of osteogenic stem cells and the stimulation of angiogenesis seem to be promoted by contact with bioactive glasses [8] For these reasons, a new promising research field has been recently proposed—i.e., the “genetic design” of new bioactive glass formulations [11] by doping silicate and phosphate glasses with several active ions, including trace elements [12,13]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
