Abstract
Genus Aspergillus represents a widely spread genus of fungi that is highly popular for possessing potent medicinal potential comprising mainly antimicrobial, cytotoxic and antioxidant properties. They are highly attributed to its richness by alkaloids, terpenes, steroids and polyketons. This review aimed to comprehensively explore the diverse alkaloids isolated and identified from different species of genus Aspergillus that were found to be associated with different marine organisms regarding their chemistry and biology. Around 174 alkaloid metabolites were reported, 66 of which showed important biological activities with respect to the tested biological activities mainly comprising antiviral, antibacterial, antifungal, cytotoxic, antioxidant and antifouling activities. Besides, in silico studies on different microbial proteins comprising DNA-gyrase, topoisomerase IV, dihydrofolate reductase, transcriptional regulator TcaR (protein), and aminoglycoside nucleotidyl transferase were done for sixteen alkaloids that showed anti-infective potential for better mechanistic interpretation of their probable mode of action. The inhibitory potential of compounds vs. Angiotensin-Converting Enzyme 2 (ACE2) as an important therapeutic target combating COVID-19 infection and its complication was also examined using molecular docking. Fumigatoside E showed the best fitting within the active sites of all the examined proteins. Thus, Aspergillus species isolated from marine organisms could afford bioactive entities combating infectious diseases.
Highlights
Marine-derived fungi have gained significant attention as promising therapeutic approaches for the treatment of a wide array of human ailments and as successful tools for drug discovery [1]
Versiquinazolines P and Q displayed potent prohibition of thioredoxin reductase (TrxR) revealing IC50 of 13.6 and 12.2 μM, respectively being superior in activity relative to curcumin, the positive control, with IC50 of 25 μM accompanied by weak cytotoxic effect
Around 174 alkaloid metabolites were reported from genus Aspergillus, 66 of which
Summary
Marine-derived fungi have gained significant attention as promising therapeutic approaches for the treatment of a wide array of human ailments and as successful tools for drug discovery [1] This is mainly attributed to their richness by a diverse array of secondary metabolites comprising terpenoids, alkaloids, peptides, lactones and steroids. Genus Aspegillus represents a widely spread genus of fungi that are highly popular of possessing a potent medicinal potential comprising mainly antimicrobial, cytotoxic and many alkaloids were previously isolated from marine fungi and showed a vast array of biological activities [6,7,8,9]. Continue exploring the anti-infectious potential of alkaloid derived from genus Aspergillus
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